Person running outdoors with text about improving skeletal muscles.
Timeline
What happens when you take Muscle+?

What happens when you take Muscle+?

Akkermansia MYO™ begins working within hours. Measurable strength gains register at week 12

Hour 4
Postbiotic absorbed

Postbiotic absorbed

The active components of Akkermansia MYO™ reach the gut, attach to the barrier lining and begin signaling.

Day 1 
The right signals received 

The right signals received 

Your muscle cells start to receive the right cellular signals that protect muscle from breakdown

Week 4 
Gut barrier strengthens

Gut barrier strengthens

The protective mucus layer thickens in the gut. In healthy adults, metabolic inflammation calms, and blood sugar control improves.

Week 12
Measurable strength gains

Measurable strength gains

The body burns energy more efficiently, skeletal muscle mass increases, and body fat can decline. In clinical trials, results show measurable improvement in lower leg strength and grip strength.

Beyond Week 12 
Sustained benefits

Sustained benefits

With ongoing daily consumption and healthy habits, metabolic, gut, and muscle benefits can be sustained. Your muscles evolve to a more resilient set point — supporting healthy aging over time.

Statements describing biological mechanisms between Hour 4- Week 4 are based on in vitro (cell culture) and in vivo (animal) studies. These describe what the science shows is happening at the cellular and tissue level and are not clinical claims of effects experienced by consumers at these timepoints. Week 12 outcomes were observed results from clinical trials.1,2 Individual results may vary. Statements regarding benefits beyond 12 weeks reflect continued daily use. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare provider before use if you are pregnant, breastfeeding, taking medication, or have a medical condition.

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SUBSTANTIATED CLAIMS

Live Akkermansia

Lactobacillus (probiotic)

Urolithin A

BCAA (Amino Acids)

Clinically proven to increase muscle strength

Supports muscle performance & power

Helps preserve lean muscle

Targets metabolic health at the gut level

Supports healthier body composition in overweight individuals

Supports gut barrier integrity

Designed for consistent potency and shelf stability

REFERENCES

1. Kang et al., Nutrients, 2024. Based on a randomized, placebo-controlled 12-week study of Akkermansia MYO™ in adults ages 60+ (mostly women). Mechanism of action and basic science support broader expected benefits. Individual results may vary based on biology, lifestyle, and other individual factors. 

2. Third-party clinical study, data on file. Based on a randomized, placebo-controlled 12-week study of Akkermansia MYO™ in adults ages 60-80 (mostly women). Mechanism of action and basic science support broader expected benefits. Individual results may vary based on biology, lifestyle, and other individual factors. 

3. Depommier et al., Nature Medicine, 2019. Based on a 3-month clinical study of pasteurized Akkermansia in overweight or obese adults with insulin resistance and metabolic syndrome. Individual results may vary.

FREQUENTLY ASKED QUESTIONS

Spindle Muscle+ is designed for health-invested adults, particularly those in their 40s, 50s, and beyond, who are focused on maintaining strength, mobility, and long-term resilience. 

In clinical studies, results were observed over a 12-week period. Individual results may vary depending on factors such as baseline health, activity level, and consistency of use. 

Akkermansia MYO™ is the core ingredient in Spindle Muscle+ and the first Akkermansia strain clinically shown to support muscle strength. 

This pasteurized (non-live) postbiotic builds on decades of microbiome research around Akkermansia muciniphila and has been studied in placebo-controlled clinical trials for its impact on muscle strength and related biomarkers.

Yes. The core ingredient, Akkermansia MYO™, has been tested in a 12-week randomized, double-blind, placebo-controlled study in adults aged 60+, where it improved muscle strength by approximately 10 percentage points vs. placebo. It has also been shown to significantly reduce myostatin, a key inhibitor of muscle growth. 

Spindle Muscle+ is made with non-drug ingredients and produced in an FDA-registered facility with an FDA-reviewed New Dietary Ingredient (NDI). It is gluten-free, non-GMO, and free from common allergens (egg, soy, wheat, nuts, fish/shellfish), with no artificial sweeteners, color additives, or preservatives. 

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